Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats
Joint Authors
Asmawi, Mohd Zaini
Yam, Mun Fei
Fung Ang, Lee
Ahmad, Mariam
Mohamed, Elsnoussi Ali
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity.
In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α-glucosidase in normal rats loaded with starch and sucrose.
The results showed that 1000 mg/kg of the 50% ethanolic extract of O.
stamineus significantly ( P < 0.05 ) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose.
In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly ( P < 0.05 ) lower plasma glucose levels after starch loading.
Hence, α-glucosidase inhibition might be one of the mechanisms by which O.
stamineus extract exerts its antidiabetic effect.
Furthermore, our findings indicated that the 50% ethanolic extract of O.
stamineus can be considered as a potential agent for the management of diabetes mellitus.
American Psychological Association (APA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. 2015. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
Modern Language Association (MLA)
Mohamed, Elsnoussi Ali…[et al.]. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
American Medical Association (AMA)
Mohamed, Elsnoussi Ali& Ahmad, Mariam& Fung Ang, Lee& Asmawi, Mohd Zaini& Yam, Mun Fei. Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063563