Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice
Joint Authors
Hossain, Hemayet
Jahan, Ismet Ara
Khatun, Amina
Rahman, Mahmudur
Nesa, Mst. Luthfun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cnicus arvensis is used by many ethnic groups for inflammation, pain, and other ailments.
In this study, reducing sugar, carbohydrate, alkaloid, steroid, tannin, flavonoid, and saponin groups were identified using standard chromogenic method.
In high-performance liquid chromatography, vanillic acid and epicatechin were identified in the extract.
Antinociceptive test by acetic acid induced writhing inhibition resulted 43.17 and 95.08% inhibition for 100 and 200 mg/kg body weight, comparing with standard diclofenac Na with 74.86% inhibition for 25 mg/kg body weight.
In formalin induced paw licking test for antinociceptive activity, the extract inhibited 69.87 and 75.55% licking for 150 and 300 mg/kg body weight comparing with the inhibition (68.56%) of diclofenac Na for 10 mg/kg body weight at first phase.
At late phase, the extract showed 73.12 and 87.46% licking comparing with licking inhibition (71.69%) by diclofenac Na at the same dose.
In open field test for CNS depressant activity, the extract showed depression of locomotor activity for 150 and 300 mg/kg body weight comparing with diazepam for 10 mg/kg body weight.
All results were statistically significant (P<0.01).
The identified polyphenols are reputed for antinociceptive and CNS depressant activity.
The present findings support the use of this plant in pain.
American Psychological Association (APA)
Rahman, Mahmudur& Khatun, Amina& Nesa, Mst. Luthfun& Hossain, Hemayet& Jahan, Ismet Ara. 2015. Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063600
Modern Language Association (MLA)
Rahman, Mahmudur…[et al.]. Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063600
American Medical Association (AMA)
Rahman, Mahmudur& Khatun, Amina& Nesa, Mst. Luthfun& Hossain, Hemayet& Jahan, Ismet Ara. Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063600