1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment
Joint Authors
Xu, Jingjing
Cheng, Kian-Kai
Wang, Chao
Shen, Guiping
Wang, Yadong
Liu, Qiong
Dong, Jiyang
Yang, Zhongbao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gastric mucosal lesion (GML) is a common gastrointestinal disorder with multiple pathogenic mechanisms in clinical practice.
In traditional Chinese medicine (TCM), electroacupuncture (EA) treatment has been proven as an effective therapy for GML, although the underlying healing mechanism is not yet clear.
Here, we used proton nuclear magnetic resonance- (1H NMR-) based metabolomic method to investigate the metabolic perturbation induced by GML and the therapeutic effect of EA treatment on stomach meridian (SM) acupoints.
Clear metabolic differences were observed between GML and control groups, and related metabolic pathways were discussed by means of online metabolic network analysis toolbox.
By comparing the endogenous metabolites from GML and GML-SM groups, the disturbed pathways were partly recovered towards healthy state via EA treated on SM acupoints.
Further comparison of the metabolic variations induced by EA stimulated on SM and the control gallbladder meridian (GM) acupoints showed a quite similar metabolite composition except for increased phenylacetylglycine, 3,4-dihydroxymandelate, and meta-hydroxyphenylacetate and decreased N-methylnicotinamide in urine from rats with EA treated on SM acupoints.
The current study showed the potential application of metabolomics in providing further insight into the molecular mechanism of acupuncture.
American Psychological Association (APA)
Xu, Jingjing& Cheng, Kian-Kai& Yang, Zhongbao& Wang, Chao& Shen, Guiping& Wang, Yadong…[et al.]. 2015. 1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063607
Modern Language Association (MLA)
Xu, Jingjing…[et al.]. 1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063607
American Medical Association (AMA)
Xu, Jingjing& Cheng, Kian-Kai& Yang, Zhongbao& Wang, Chao& Shen, Guiping& Wang, Yadong…[et al.]. 1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063607