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Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats
Joint Authors
Choi, Ho-Young
Kim, Bumjung
Hur, Heseung
Chinannai, Khanita Suman
Ham, Inhye
Lee, Kyungjin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study was designed to evaluate the antihypertensive effect of GaMiSamHwangSaSimTang (HVC1), a 30% ethanol extract of a mixture comprising Pruni Cortex, Scutellariae Radix, Coptidis Rhizoma, and Rhei Rhizoma, on spontaneous hypertensive rats (SHRs).
The systolic blood pressure (SBP) was measured every 4 or 7 days using the noninvasive tail cuff system.
The vasorelaxant effects on isolated aortic rings were evaluated.
Aortic rings were contracted using phenylephrine (PE) or KCl, and the changes in tension were recorded via isometric transducers connected to a data acquisition system.
In this study, oral administration of HVC1 decreased the SBP of SHRs over the experimental period.
HVC1 induced concentration-dependent relaxation in the aortic rings that had been precontracted using PE or KCl.
The vasorelaxant effects of HVC1 on endothelium-intact aortic rings were inhibited by pretreatment with Nω-Nitro-l-arginine methyl ester (L-NAME) or methylene blue.
HVC1 inhibited the contraction induced by extracellular Ca2+ in endothelium-denuded rat aortic rings that had been precontracted using PE or KCl.
In conclusion, HVC1 reduced the SBP of SHR and relaxed isolated SHR aortic rings by upregulating NO formation and the NO-cGMP pathway and blocking the entry of extracellular Ca2+ via receptor-operative Ca2+ channel and voltage-dependent Ca2+ channel.
American Psychological Association (APA)
Lee, Kyungjin& Kim, Bumjung& Hur, Heseung& Chinannai, Khanita Suman& Ham, Inhye& Choi, Ho-Young. 2015. Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063608
Modern Language Association (MLA)
Lee, Kyungjin…[et al.]. Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063608
American Medical Association (AMA)
Lee, Kyungjin& Kim, Bumjung& Hur, Heseung& Chinannai, Khanita Suman& Ham, Inhye& Choi, Ho-Young. Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063608