Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review
Joint Authors
Hua, Hong
Zhou, Tingting
Zhou, Peiru
Liu, Xiaosong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM) for pemphigus.
Methods.
Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs) or clinical controlled trials (CCTs) that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language.
Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures.
The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software.
Results.
Four RCTs with a total of 199 patients were included in the present review.
Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level.
The trials were not of high methodological quality.
No study mentioned allocation concealment and blinding.
Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain.
Conclusion.
There is some, albeit weak, evidence to show that combined treatment with corticosteroids with TCM could be of benefit for some patients with pemphigus.
The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.
American Psychological Association (APA)
Zhou, Tingting& Zhou, Peiru& Hua, Hong& Liu, Xiaosong. 2015. Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063623
Modern Language Association (MLA)
Zhou, Tingting…[et al.]. Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063623
American Medical Association (AMA)
Zhou, Tingting& Zhou, Peiru& Hua, Hong& Liu, Xiaosong. Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063623