Panax ginseng Improves Functional Recovery after Contusive Spinal Cord Injury by Regulating the Inflammatory Response in Rats: An In Vivo Study
Joint Authors
Valan Arasu, Mariadhas
Kim, Junesun
Kim, Young Ock
Kim, Youngkyung
Lee, Koeun
Na, Sae Won
Hong, Seon Pyo
Yoon, Young Wook
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Spinal cord injury (SCI) results in permanent loss of motor function below the injured site.
Neuroinflammatory reaction following SCI can aggravate neural injury and functional impairment.
Ginseng is well known to possess anti-inflammatory effects.
The present study investigated the neuroprotective effects of Panax ginseng C.A.
Mayer (P.
ginseng) after SCI.
A spinal contusion was made at the T11-12 spinal cord in adult male Sprague-Dawley rats ( n = 47 ) using the NYU impactor.
Motor function was assessed using the Basso-Beattie-Bresnahan (BBB) score in P.
ginseng (0.1, 0.5, 1, 3, and 5 mg/kg) or vehicle (saline) treated after SCI.
We also assessed the protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) at the lesion site by western blot and then measured the cavity area using luxol fast blue/cresyl violet staining.
P.
ginseng treated group in SCI showed a significant improvement in locomotor function after the injury.
The protein expression of COX-2 and iNOS at the lesion site and the cavity area were decreased following SCI by P.
ginseng treatment.
These results suggest that P.
ginseng may improve the recovery of motor function after SCI which provides neuroprotection by alleviating posttraumatic inflammatory responses.
American Psychological Association (APA)
Kim, Young Ock& Kim, Youngkyung& Lee, Koeun& Na, Sae Won& Hong, Seon Pyo& Valan Arasu, Mariadhas…[et al.]. 2015. Panax ginseng Improves Functional Recovery after Contusive Spinal Cord Injury by Regulating the Inflammatory Response in Rats: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063627
Modern Language Association (MLA)
Kim, Young Ock…[et al.]. Panax ginseng Improves Functional Recovery after Contusive Spinal Cord Injury by Regulating the Inflammatory Response in Rats: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063627
American Medical Association (AMA)
Kim, Young Ock& Kim, Youngkyung& Lee, Koeun& Na, Sae Won& Hong, Seon Pyo& Valan Arasu, Mariadhas…[et al.]. Panax ginseng Improves Functional Recovery after Contusive Spinal Cord Injury by Regulating the Inflammatory Response in Rats: An In Vivo Study. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063627