Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
Joint Authors
Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction.
This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin.
Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively.
In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.
American Psychological Association (APA)
Saengsai, Jutamas& Kongtunjanphuk, Sumonthip& Yoswatthana, Nuttawan& Kummalue, Tanawan& Jiratchariyakul, Weena. 2015. Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063641
Modern Language Association (MLA)
Saengsai, Jutamas…[et al.]. Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063641
American Medical Association (AMA)
Saengsai, Jutamas& Kongtunjanphuk, Sumonthip& Yoswatthana, Nuttawan& Kummalue, Tanawan& Jiratchariyakul, Weena. Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063641
