Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats
Joint Authors
Lu, Li
Zhijian, Huang
Lei, Li
Wenchuan, Chen
Zhimin, Zhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study evaluated the effects of berberine in combination with insulin on early osseointegration of implants in diabetic rats.
Fifty male Sprague-Dawley rats were randomly divided into 5 groups: healthy rats were used as control (HC), and streptozotocin-induced diabetic rats were treated with insulin, berberine, berberine + insulin (IB), or no treatment.
Each rat received one machined-surface cp-Ti implant into the right tibia and was given insulin injection and/or gavage feeding with berberine daily for 8 weeks until being sacrificed.
Serum levels of alkaline phosphatase (ALP) and bone gamma-carboxyglutamic acid-containing protein (BGP) were analyzed in each group.
Peri-implant mineral apposition was marked by fluorochrome double-labeling and osseointegration was histomorphologically examined.
The ALP and BGP levels decreased in diabetic rats but were successfully corrected by insulin and berberine combined treatment.
Moreover, untreated diabetic rats had less labeled mineral apposition and impaired osseointegration.
In contrast, Groups I, B, and IB were observed with increased peri-implant bone formation.
The combination treatment of insulin and berberine was more effective than each administrated as a monotherapy.
These results suggest that berberine combined with insulin could promote osseointegration in diabetic rats, thereby highlighting its potential application to patients, though further studies are needed.
American Psychological Association (APA)
Lu, Li & Zhijian, Huang & Lei, Li & Wenchuan, Chen & Zhimin, Zhu. 2015. Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063648
Modern Language Association (MLA)
Lu, Li…[et al.]. Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063648
American Medical Association (AMA)
Lu, Li & Zhijian, Huang & Lei, Li & Wenchuan, Chen & Zhimin, Zhu. Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063648