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Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells
Joint Authors
Bhummaphan, Narumol
Chanvorachote, Pithi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As cancer stem cells (CSCs) contribute to malignancy, metastasis, and relapse of cancers, potential of compound in inhibition of CSCs has garnered most attention in the cancer research as well as drug development fields recently.
Herein, we have demonstrated for the first time that gigantol, a pure compound isolated from Dendrobium draconis, dramatically suppressed stem-like phenotypes of human lung cancer cells.
Gigantol at nontoxic concentrations significantly reduced anchorage-independent growth and survival of the cancer cells.
Importantly, gigantol significantly reduced the ability of the cancer cells to form tumor spheroids, a critical hallmark of CSCs.
Concomitantly, the treatment of the compound was shown to reduce well-known lung CSCs markers, including CD133 and ALDH1A1.
Moreover, we revealed that gigantol decreased stemness in the cancer cells by suppressing the activation of protein kinase B (Akt) signal which in turn decreased the cellular levels of pluripotency and self-renewal factors Oct4 and Nanog.
In conclusion, gigantol possesses CSCs suppressing activity which may facilitate the development of this compound for therapeutic approaches by targeting CSCs.
American Psychological Association (APA)
Bhummaphan, Narumol& Chanvorachote, Pithi. 2015. Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063668
Modern Language Association (MLA)
Bhummaphan, Narumol& Chanvorachote, Pithi. Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063668
American Medical Association (AMA)
Bhummaphan, Narumol& Chanvorachote, Pithi. Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063668