Biocompatibility of Bletilla striata Microspheres as a Novel Embolic Agent
Joint Authors
Luo, ShiHua
Song, SongLin
Zheng, ChuanSheng
Wang, Yong
Xia, XiangWen
Liang, Bin
Feng, GanSheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We have prepared Chinese traditional herb Bletilla striata into microspheres as a novel embolic agent for decades.
The aim of this study was to evaluate the biocompatibility of Bletilla striata microspheres (BSMs).
After a thermal test of BSMs in vitro, the cell biocompatibility of BSMs was investigated in mouse fibroblasts and human umbilical vein endothelial cells using the methyl tetrazolium (MTT) assay.
In addition, blood biocompatibility was evaluated.
In vivo intramuscular implantation and renal artery embolization in rabbits with BSMs were used to examine the inflammatory response.
The experimental rabbits did not develop any fever symptoms after injection of BSMs, and BSMs exhibited no cytotoxicity in cultured mouse fibroblasts and human umbilical vein endothelial cells.
Additionally, BSMs exhibited high compatibility with red blood cells and no hemolysis activity.
Intramuscular implantation with BSMs resulted in a gradually lessened mild inflammatory reaction that disappeared after eight weeks.
The occlusion of small renal vessels was associated with a mild perivascular inflammatory reaction without significant renal and liver function damage.
In conclusion, we believe that BSMs exhibit high biocompatibility and are a promising embolic agent.
American Psychological Association (APA)
Luo, ShiHua& Song, SongLin& Zheng, ChuanSheng& Wang, Yong& Xia, XiangWen& Liang, Bin…[et al.]. 2015. Biocompatibility of Bletilla striata Microspheres as a Novel Embolic Agent. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063673
Modern Language Association (MLA)
Luo, ShiHua…[et al.]. Biocompatibility of Bletilla striata Microspheres as a Novel Embolic Agent. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063673
American Medical Association (AMA)
Luo, ShiHua& Song, SongLin& Zheng, ChuanSheng& Wang, Yong& Xia, XiangWen& Liang, Bin…[et al.]. Biocompatibility of Bletilla striata Microspheres as a Novel Embolic Agent. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063673