Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture
Joint Authors
Li, Qian
Wang, Yan-Qing
Liu, Huan
Liu, Shen-Bin
Wang, Huijing
Mao-Ying, Qi-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acupuncture or electroacupuncture (EA) has been demonstrated to have a powerful antihypernociceptive effect on inflammatory pain.
The attenuation of G protein-coupled receptor kinase 2 (GRK2) in spinal cord and peripheral nociceptor has been widely acknowledged to promote the transition from acute to chronic pain and to facilitate the nociceptive progress.
This study was designed to investigate the possible role of spinal GRK2 in EA antiallodynic in a rat model with complete Freund’s adjuvant (CFA) induced inflammatory pain.
EA was applied to ST36 (“Zusanli”) and BL60 (“Kunlun”) one day after CFA injection.
Single EA treatment at day 1 after CFA injection remarkably alleviated CFA induced mechanical allodynia two hours after EA.
Repeated EA displayed significant antiallodynic effect from 2nd EA treatment and a persistent effect was observed during the rest of treatments.
However, downregulation of spinal GRK2 by intrathecal exposure of GRK2 antisense 30 mins after EA treatment completely eliminated both the transient and persistent antiallodynic effect by EA treatment.
These pieces of data demonstrated that the spinal GRK2 played an important role in EA antiallodynia on inflammatory pain.
American Psychological Association (APA)
Liu, Huan& Liu, Shen-Bin& Li, Qian& Wang, Huijing& Wang, Yan-Qing& Mao-Ying, Qi-Liang. 2015. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063679
Modern Language Association (MLA)
Liu, Huan…[et al.]. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063679
American Medical Association (AMA)
Liu, Huan& Liu, Shen-Bin& Li, Qian& Wang, Huijing& Wang, Yan-Qing& Mao-Ying, Qi-Liang. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063679