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Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B
Joint Authors
Mazzio, Elizabeth
Eyunni, Suresh
Elshami, Faisel
Zarmouh, Najla O.
Messeha, Samia S.
Soliman, Karam F. A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Monoamine oxidase B inhibitors (MAO-BIs) are used in the early management of Parkinson’s disease (PD).
Long-term suspected side effects of MAO-B classical inhibitors established the need for safer alternative therapeutic agents.
In our study, the flavanone bavachinin (BNN) and its analog bavachin (BVN) found in the seeds of Psoralea corylifolia L.
ethanolic extract (PCSEE) were investigated for their human MAO-A and MAO-B (hMAO-A and hMAO-B) inhibition.
Both PCSEE and BNN effectively reduced hMAO-B activity more than hMAO-A while BVN had activating effects.
BNN showed selective hMAO-B inhibition (IC50 ~ 8.82 μM) more than hMAO-A (IC502009;~ 189.28 μM).
BNN in the crude extract was determined by HPLC, also validated by TLC showing a yield of 0.21% PCSEE dry weight.
BNN competitively inhibited hMAO-A and hMAO-B, with a lower hMAO-B K i than hMAO-A K i by 10.33-fold, and reduced hMAO-B K m / V m a x efficiency ratio to be comparable to the standard selegiline.
Molecular docking examination of BNN and BVN predicted an indirect role of BNN C7-methoxy group for its higher affinity, selectivity, and reversibility as an MAO-BI.
These findings suggest that BNN, which is known to be a potent PPAR-γ agonist, is a selective and competitive hMAO-B inhibitor and could be used in the management of PD.
American Psychological Association (APA)
Zarmouh, Najla O.& Mazzio, Elizabeth& Elshami, Faisel& Messeha, Samia S.& Eyunni, Suresh& Soliman, Karam F. A.. 2015. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063683
Modern Language Association (MLA)
Zarmouh, Najla O.…[et al.]. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1063683
American Medical Association (AMA)
Zarmouh, Najla O.& Mazzio, Elizabeth& Elshami, Faisel& Messeha, Samia S.& Eyunni, Suresh& Soliman, Karam F. A.. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1063683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063683