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Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells
Joint Authors
Eid, Safaa Yehia
El-Readi, Mahmoud Zaki
Ashour, Mohamed Lotfy
Wink, Michael
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Resistance of cancer cells to chemotherapy is controlled by the decrease of intracellular drug accumulation, increase of detoxification, and diminished propensity of cancer cells to undergo apoptosis.
ATP-binding cassette (ABC) membrane transporters with intracellular metabolic enzymes contribute to the complex and unresolved phenomenon of multidrug resistance (MDR).
Natural products as alternative medicine have great potential to discover new MDR inhibitors with diverse modes of action.
In this study, we characterized several extracts of traditional Chinese medicine (TCM) plants (N = 16) for their interaction with ABC transporters, cytochrome P3A4 (CYP3A4), and glutathione-S-transferase (GST) activities and their cytotoxic effect on different cancer cell lines.
Fallopia japonica (FJ) (Polygonaceae) shows potent inhibitory effect on CYP3A4 P-glycoprotein activity about 1.8-fold when compared to verapamil as positive control.
FJ shows significant inhibitory effect (39.81%) compared with the known inhibitor ketoconazole and 100 μg/mL inhibited GST activity to 14 μmol/min/mL.
FJ shows moderate cytotoxicity in human Caco-2, HepG-2, and HeLa cell lines; IC50 values were 630.98, 198.80, and 317.37 µg/mL, respectively.
LC-ESI-MS were used to identify and quantify the most abundant compounds, emodin, polydatin, and resveratrol, in the most active extract of FJ.
Here, we present the prospect of using Fallopia japonica as natural products to modulate the function of ABC drug transporters.
We are conducting future study to evaluate the ability of the major active secondary metabolites of Fallopia japonica to modulate MDR and their impact in case of failure of chemotherapy.
American Psychological Association (APA)
Eid, Safaa Yehia& El-Readi, Mahmoud Zaki& Ashour, Mohamed Lotfy& Wink, Michael. 2015. Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063702
Modern Language Association (MLA)
Eid, Safaa Yehia…[et al.]. Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063702
American Medical Association (AMA)
Eid, Safaa Yehia& El-Readi, Mahmoud Zaki& Ashour, Mohamed Lotfy& Wink, Michael. Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063702