Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain
Joint Authors
Kuraishi, Yasushi
Andoh, Tsugunobu
Ebisawa, Shigeru
Shimada, Yutaka
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neuropathic pain is caused by nerve injury.
Yokukansan (Yi-Gan San), a traditional Japanese (Kampo) medicine, has been widely used for neuropathic pain control.
However, the analgesic mechanisms remain unknown.
In this study, we investigated the analgesic mechanisms of yokukansan in a mouse model of neuropathic pain.
Partial sciatic nerve ligation (PSL) induced mechanical allodynia in mice.
Repetitive oral administration of the extracts of yokukansan and the constituent herbal medicine Atractylodis Lanceae Rhizoma, but not Glycyrrhizae Radix, relieved mechanical allodynia in the PSL mice and inhibited the PSL-induced expression of interleukin- (IL-) 6 mRNA in the spinal cord.
Yokukansan did not attenuate intrathecal IL-6-induced mechanical allodynia.
IL-6 immunoreactivity was detected in microglia and astrocytes in the spinal dorsal horn.
These results suggest that yokukansan relieves mechanical allodynia in PSL mice by regulating the expression of IL-6 in astrocytes and/or microglia in the spinal cord.
In addition, the components of Atractylodis Lanceae Rhizoma, one of the constituent herbal medicines in yokukansan, may play an important role in the regulation of IL-6 expression and neuropathic pain control.
American Psychological Association (APA)
Ebisawa, Shigeru& Andoh, Tsugunobu& Shimada, Yutaka& Kuraishi, Yasushi. 2015. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063708
Modern Language Association (MLA)
Ebisawa, Shigeru…[et al.]. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063708
American Medical Association (AMA)
Ebisawa, Shigeru& Andoh, Tsugunobu& Shimada, Yutaka& Kuraishi, Yasushi. Yokukansan Improves Mechanical Allodynia through the Regulation of Interleukin-6 Expression in the Spinal Cord in Mice with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063708