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Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study
Joint Authors
Chen, Xiang
Hu, Chao
Dai, Jican
Chen, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) is an important treatment for male infertility, and its application to therapy is dependent on differentiation of TCM syndromes.
This study aims to investigate the changes in metabolites and metabolic pathways in infertile males with Kidney-Yang Deficiency syndrome (KYDS) via metabolomics approaches.
Seminal plasma samples were collected from 18 infertile males with KYDS and 18 fertile males.
Liquid chromatography and mass spectrometry were used to characterize metabolomics profiles.
Principal component analysis (PCA), partial least squares-discriminate analysis (PLS-DA), and pathway analysis were used for pattern recognition and metabolite identification.
PCA and PLS-DA results differentiated the two groups of patients.
Forty-one discriminating metabolites (18 in positive mode and 23 in negative mode) were identified.
Seven metabolites were related to five potential metabolic pathways associated with biosynthesis and metabolism of aromatic amino acids, tricarboxylic acid cycle, and sphingolipid metabolism.
The changes in metabolic pathways may play an important role in the origin of KYDS-associated male infertility.
Metabolomics analysis of seminal plasma may be used to differentiate TCM syndromes of infertile males, but further research must be conducted.
American Psychological Association (APA)
Chen, Xiang& Hu, Chao& Dai, Jican& Chen, Lei. 2015. Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063724
Modern Language Association (MLA)
Chen, Xiang…[et al.]. Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063724
American Medical Association (AMA)
Chen, Xiang& Hu, Chao& Dai, Jican& Chen, Lei. Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063724