The Nociceptive and Anti-Inflammatory Effects of Artemisia dracunculus L. Aqueous Extract on Fructose Fed Male Rats
Joint Authors
Mohammad Reza, Shahraki
Hamideh, Mirshekari
Zahra, Samadi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim & Objective.
Artemisia dracunculus L.
(Tarragon) species have been used as a traditional medicine.
The present study was designed to evaluate the nociceptive and anti-inflammatory effects of A.
dracunculus L.
leaf aqueous extract on fructose drinking water (FDW) in male rats.
Materials & Methods.
Forty-eight Wistar-albino male rats weighing 200–250 g were divided into control (C), control extract (CE), FDW, and FDWE groups (n=12).
Group C did not receive any agents; Group CE did 100 mg/kg A.
dracunculus L.
aqueous extract on a daily basis for duration of four weeks.
FDW Group received fructose drinking water (10%, weight/volume) but did not receive any agents during trial period.
FDWE group received 100 mg/kg A.
dracunculus L.
aqueous extract during trial period.
At the end of experiment, a biphasic pain response was induced following interplanetary injection of formalin (50 µL, 1%).
Obtained data were analyzed using SPSS software version 17 and using ANOVA and Tukey post hoc tests.
Results were expressed as mean ± SE.
Statistical differences were considered significant at P<0.05.
Results.
Our findings revealed that acute and chronic pain scores in FDW group are significantly higher than other ones and A.
dracunculus L.
aqueous extract causes significant decreasing of this parameter in FDWE group (P<0.001).
Moreover, IL6 and TNF values in this group were significantly decreased compared to FDW group (P<0.05).
Conclusion.
Results in the present study show that FDW causes the pain response score to increase and cause proinflammatory cytokines in rat model but A.
dracunculus L.
leaf aqueous extract improves values of these parameters.
American Psychological Association (APA)
Mohammad Reza, Shahraki& Hamideh, Mirshekari& Zahra, Samadi. 2015. The Nociceptive and Anti-Inflammatory Effects of Artemisia dracunculus L. Aqueous Extract on Fructose Fed Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063727
Modern Language Association (MLA)
Mohammad Reza, Shahraki…[et al.]. The Nociceptive and Anti-Inflammatory Effects of Artemisia dracunculus L. Aqueous Extract on Fructose Fed Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063727
American Medical Association (AMA)
Mohammad Reza, Shahraki& Hamideh, Mirshekari& Zahra, Samadi. The Nociceptive and Anti-Inflammatory Effects of Artemisia dracunculus L. Aqueous Extract on Fructose Fed Male Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063727