The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial
Joint Authors
Giacosa, A.
Rondanelli, Mariangela
Faliva, Milena
Guido, Davide
Grassi, Mario
Riva, Antonella
Morazzoni, Paolo
Bombardelli, Ezio
Perna, Simone
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Functional dyspepsia (FD) is a frequent clinical finding in western world.
The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD.
Methods.
A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed.
Two capsules/day were supplied (before lunch and dinner) to 126 FD patients (supplementation/placebo: 65/61).
Results.
After 14 days of treatment, only supplementation group (SG) showed a significant amelioration (SG: αS=+1.195 MCA score units (u), P=0.017; placebo: αP=+0.347 u, P=0.513).
The intercept (α) resulted to be significantly higher in SG than in placebo (αS-αP=+0.848 u, P<0.001).
At the end of the study, the advantage of SG versus placebo persists without variation (βS-βP=+0.077 u, P=0.542).
In SG, a significant advantage is observed for nausea (βS-βP=-0.398 u, P<0.001), epigastric fullness (βS-βP=-0.241, P<0.001), epigastric pain (βS-βP=-0.173 u, P=0.002), and bloating (βS-βP=-0.167 u, P=0.017).
Conclusions.
The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.
American Psychological Association (APA)
Giacosa, A.& Guido, Davide& Grassi, Mario& Riva, Antonella& Morazzoni, Paolo& Bombardelli, Ezio…[et al.]. 2015. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063792
Modern Language Association (MLA)
Giacosa, A.…[et al.]. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063792
American Medical Association (AMA)
Giacosa, A.& Guido, Davide& Grassi, Mario& Riva, Antonella& Morazzoni, Paolo& Bombardelli, Ezio…[et al.]. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063792