Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.
Joint Authors
Mendonça Junior, F. J. B.
Lima, Edeltrudes Oliveira
Sousa, Janiere Pereira de
Guerra, Felipe Queiroga Sarmento
Araújo, Rodrigo Santos Aquino de
Pereira, Fillipe de Oliveira
Barbosa-Filho, José M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aspergillus spp.
produce a wide variety of diseases.
For the treatment of such infections, the azoles and Amphotericin B are used in various formulations.
The treatment of fungal diseases is often ineffective, because of increases in azole resistance and their several associated adverse effects.
To overcome these problems, natural products and their derivatives are interesting alternatives.
The aim of this study was to examine the effects of coumarin derivative, 7-hydroxy-6-nitro-2H-1-benzopyran-2-one (Cou-NO2), both alone and with antifungal drugs.
Its mode of action against Aspergillus spp.
Cou-NO2 was tested to evaluate its effects on mycelia growth and germination of fungal conidia of Aspergillus spp.
We also investigated possible Cou-NO2 action on cell walls (0.8 M sorbitol) and on Cou-NO2 to ergosterol binding in the cell membrane.
The study shows that Cou-NO2 is capable of inhibiting both the mycelia growth and germination of conidia for the species tested, and that its action affects the structure of the fungal cell wall.
At subinhibitory concentration, Cou-NO2 enhanced the in vitro effects of azoles.
Moreover, in combination with azoles (voriconazole and itraconazole) Cou-NO2 displays an additive effect.
Thus, our study supports the use of coumarin derivative 7-hydroxy-6-nitro-2H-1-benzopyran-2-one as an antifungal agent against Aspergillus species.
American Psychological Association (APA)
Guerra, Felipe Queiroga Sarmento& Araújo, Rodrigo Santos Aquino de& Sousa, Janiere Pereira de& Pereira, Fillipe de Oliveira& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.…[et al.]. 2015. Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063806
Modern Language Association (MLA)
Guerra, Felipe Queiroga Sarmento…[et al.]. Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063806
American Medical Association (AMA)
Guerra, Felipe Queiroga Sarmento& Araújo, Rodrigo Santos Aquino de& Sousa, Janiere Pereira de& Pereira, Fillipe de Oliveira& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.…[et al.]. Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063806