The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice
Joint Authors
Kim, Youn-Chul
Oh, Hyun Cheol
Kim, Dae Sung
Yoon, Chi-Su
Baral, Samrat
Cho, Du-Hyong
Pariyar, Ramesh
Chang, Bo-yoon
Cho, Hyoung-Kwon
Kim, Sung Yeon
Kim, Jaehyo
Seo, Jungwon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myrrh has been used since ancient times for the treatment of various diseases such as inflammatory diseases, gynecological diseases, and hemiplegia.
In the present study, we investigated the effects of aqueous extracts of myrrh resin (AEM) on scopolamine-induced memory impairments in mice.
AEM was estimated with (2E,5E)-6-hydroxy-2,6-dimethylhepta-2,4-dienal as a representative constituent by HPLC.
The oral administration of AEM for 7 days significantly reversed scopolamine-induced reduction of spontaneous alternation in the Y -maze test.
In the passive avoidance task, AEM also restored the decreased latency time of the retention trial by scopolamine treatment.
In addition, Western blot analysis and Immunohistochemistry revealed that AEM reversed scopolamine-decreased phosphorylation of Akt and extracellular signal-regulated kinase (ERK).
Our study demonstrates for the first time that AEM ameliorates the scopolamine-induced memory impairments in mice and increases the phosphorylation of Akt and ERK in the hippocampus of mice brain.
These results suggest that AEM has the therapeutic potential in memory impairments.
American Psychological Association (APA)
Baral, Samrat& Cho, Du-Hyong& Pariyar, Ramesh& Yoon, Chi-Su& Chang, Bo-yoon& Kim, Dae Sung…[et al.]. 2015. The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063807
Modern Language Association (MLA)
Baral, Samrat…[et al.]. The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063807
American Medical Association (AMA)
Baral, Samrat& Cho, Du-Hyong& Pariyar, Ramesh& Yoon, Chi-Su& Chang, Bo-yoon& Kim, Dae Sung…[et al.]. The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063807