Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation
Joint Authors
Xu, Tongda
Li, Dongye
Zhu, Hong
Lang, Yasong
Cao, Lijuan
Liu, Yang
Wu, Wanling
Chen, Dan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Luteolin is a naturally occurring flavonoid found in many plants that possesses cardioprotective properties.
The purpose of this study was to elucidate the effect of luteolin on vascular smooth muscle cells (VSMCs) proliferation and migration induced by Angiotensin II (Ang II) and to investigate the mechanism(s) of action of this compound.
Rat VSMCs were cultured in vitro, and the proliferation and migration of these cells following Ang II stimulation were monitored.
Different doses of luteolin were added to VSMC cultures, and the proliferation and migration rate were observed by MTT and Transwell chamber assays, respectively.
In addition, the expressions of p-Akt (308), p-Akt (473), and proliferative cell nuclear antigen (PCNA) in VSMCs were monitored by Western blotting.
This study demonstrated that luteolin has an inhibitory effect on Ang II-induced VSMC proliferation and migration.
Further, the levels of p-Akt (308), p-Akt (473), and PCNA were reduced in VSMCs treated with both Ang II and luteolin compared to VSMCs treated with only Ang II.
These findings strongly suggest that luteolin inhibits Ang II-stimulated proliferation and migration of VSMCs, which is partially due to downregulation of the Akt signaling pathway.
American Psychological Association (APA)
Xu, Tongda& Zhu, Hong& Li, Dongye& Lang, Yasong& Cao, Lijuan& Liu, Yang…[et al.]. 2015. Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063818
Modern Language Association (MLA)
Xu, Tongda…[et al.]. Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063818
American Medical Association (AMA)
Xu, Tongda& Zhu, Hong& Li, Dongye& Lang, Yasong& Cao, Lijuan& Liu, Yang…[et al.]. Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063818