The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats
Joint Authors
Hu, Dayi
Guo, Rong
Ge, Yingxiao
Li, Gang
Guo, Huixin
Wang, Dongzhi
Jie, Qiqiang
Hou, Lei
Wei, Yidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lacidipine (LAC) is now widely used for the treatment of hypertension and further can prevent cardiac hypertrophy and remodeling.
However, the underlying mechanism has not been fully understood.
In this study, we examined the protective effects of LAC on cardiac remodeling in spontaneously hypertensive rats (SHR) and investigated the possible mechanism.
Four weeks after administration of the designated drugs, blood pressure, left ventricular mass index (LVMI), and rterial pressure (MAP) were measured.
The endoplasmic reticulum stress (ERS) parameters such as GRP78 and CHOP expressions in cardiomyocytes were also detected by immunohistochemistry.
Results showed that the MAP in 0.36 and 0.72 mg/kg LAC groups was markedly lowered compared with that of the SHR control group ( P < 0.01 or P < 0.05 ).
Moreover, 0.72 mg/kg LAC could also significantly decrease the LVMI ( P < 0.05 ).
Simultaneously, the results of immunohistochemistry demonstrated that the expression of GRP78 and CHOP was significantly decreased by 0.72 mg/kg LAC ( P < 0.05 ), respectively.
Our present study suggested that LAC could lower blood pressure and could prevent left ventricular hypertrophy accompanied by inhibiting expression of GRP78 and CHOP in ERS.
American Psychological Association (APA)
Ge, Yingxiao& Li, Gang& Guo, Rong& Guo, Huixin& Wang, Dongzhi& Jie, Qiqiang…[et al.]. 2015. The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063828
Modern Language Association (MLA)
Ge, Yingxiao…[et al.]. The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063828
American Medical Association (AMA)
Ge, Yingxiao& Li, Gang& Guo, Rong& Guo, Huixin& Wang, Dongzhi& Jie, Qiqiang…[et al.]. The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063828