Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats
Joint Authors
Zhang, Liangjun
Cheng, Ying
Du, Xiaohuang
Chen, Sheng
Feng, Xinchan
Gao, Yu
Li, Shaoxue
Liu, Li
Yang, Mei
Chen, Lei
Peng, Zhihong
Yang, Yong
Luo, Weizao
Wang, Rongquan
Chen, Wensheng
Chai, Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Swertianlarin is an herbal agent abundantly distributed in Swertia mussotii Franch, a Chinese traditional herb used for treatment of jaundice.
To study the therapeutic effect of swertianlarin on cholestasis, liver injury, serum proinflammatory cytokines, and bile salt concentrations were measured by comparing rats treated with swertianlarin 100 mg/kg/d or saline for 3, 7, or 14 days after bile duct ligation (BDL).
Serum alanine aminotransferase (ATL) and aspartate aminotransferase (AST) levels were significantly decreased in BDL rats treated with swertianlarin for 14 days (P<0.05).
The reduced liver injury in BDL rats by swertianlarin treatment for 14 days was further confirmed by liver histopathology.
Levels of serum tumor necrosis factor alpha (TNFα) were decreased by swertianlarin in BDL rats for 3 and 7 days (P<0.05).
Moreover, reductions in serum interleukins IL-1β and IL-6 levels were also observed in BDL rats treated with swertianlarin (P<0.05).
In addition, most of serum toxic bile salt concentrations (e.g., chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA)) in cholestatic rats were decreased by swertianlarin (P<0.05).
In conclusion, the data suggest that swertianlarin derived from Swertia mussotii Franch attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.
American Psychological Association (APA)
Zhang, Liangjun& Cheng, Ying& Du, Xiaohuang& Chen, Sheng& Feng, Xinchan& Gao, Yu…[et al.]. 2015. Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063833
Modern Language Association (MLA)
Zhang, Liangjun…[et al.]. Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063833
American Medical Association (AMA)
Zhang, Liangjun& Cheng, Ying& Du, Xiaohuang& Chen, Sheng& Feng, Xinchan& Gao, Yu…[et al.]. Swertianlarin, an Herbal Agent Derived from Swertia mussotii Franch, Attenuates Liver Injury, Inflammation, and Cholestasis in Common Bile Duct-Ligated Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063833