Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves
Joint Authors
Ruiz, Ana Lúcia Tasca Gois
Vendramini-Costa, Débora B.
Rodrigues, Rodney Alexandre Ferreira
Iwamoto, Leilane Hespporte
Monteiro, Paula Araújo
Sousa, Ilza Maria de Oliveira
Foglio, Mary Ann
de Carvalho, João Ernesto
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite the advances in anticancer drug discovery field, the worldwide cancer incidence is remarkable, highlighting the need for new therapies focusing on both cancer cell and its microenvironment.
The tumor microenvironment offers multiple targets for cancer therapy, including inflammation.
Nowadays, almost 75% of the anticancer agents used in chemotherapy are derived from natural products, and plants are an important source of new promising therapies.
Continuing our research on Piper umbellatum species, here we describe the anticancer (in vitro antiproliferative activity and in vivo Ehrlich solid tumor model) and anti-inflammatory (carrageenan-induced paw edema and peritonitis models) activities of a standardized dichloromethane extract (SDE) from P.
umbellatum leaves, containing 23.9% of 4-nerolidylcatechol.
SDE showed in vitro and in vivo antiproliferative activity, reducing Ehrlich solid tumor growth by 38.7 and 52.2% when doses of 200 and 400 mg/kg, respectively, were administered daily by oral route.
Daily treatments did not produce signals of toxicity.
SDE also reduced paw edema and leukocyte migration on carrageenan-induced inflammation models, suggesting that the anticancer activity of SDE from Piper umbellatum leaves could involve antiproliferative and anti-inflammatory effects.
These findings highlight P.
umbellatum as a source of compounds against cancer and inflammation.
American Psychological Association (APA)
Iwamoto, Leilane Hespporte& Vendramini-Costa, Débora B.& Monteiro, Paula Araújo& Ruiz, Ana Lúcia Tasca Gois& Sousa, Ilza Maria de Oliveira& Foglio, Mary Ann…[et al.]. 2015. Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063834
Modern Language Association (MLA)
Iwamoto, Leilane Hespporte…[et al.]. Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063834
American Medical Association (AMA)
Iwamoto, Leilane Hespporte& Vendramini-Costa, Débora B.& Monteiro, Paula Araújo& Ruiz, Ana Lúcia Tasca Gois& Sousa, Ilza Maria de Oliveira& Foglio, Mary Ann…[et al.]. Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from Piper umbellatum L. Leaves. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063834