A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women
Joint Authors
Fava, Maurizio
Dording, Christina M.
Schettler, Pamela J.
Dalton, Elizabeth D.
Parkin, Susannah R.
Walker, Rosemary S. W.
Fehling, Kara B.
Mischoulon, David
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women.
Method.
We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female outpatients (mean age of 41.5 ± 12.5 years) with SSRI/SNRI-induced sexual dysfunction whose depression remitted.
Endpoints were improvement in sexual functioning as per the Arizona Sexual Experience Scale (ASEX) and the Massachusetts General Hospital Sexual Function Questionnaire (MGH-SFQ).
Results.
45 of 57 consented females were randomized, and 42 (30 premenopausal and 12 postmenopausal women) were eligible for a modified intent-to-treat analysis based on having had at least one postmedication visit.
Remission rates by the end of treatment were higher for the maca than the placebo group, based on attainment of an ASEX total score ≤ 10 (9.5% for maca versus 4.8% for placebo), attaining an MGH-SFQ score ≤ 12 (30.0% for maca versus 20.0% for placebo) and reaching an MGH-SFQ score ≤ 8 (9.5% for maca versus 5.0% for placebo).
Higher remission rates for the maca versus placebo group were associated with postmenopausal status.
Maca was well tolerated.
Conclusion.
Maca root may alleviate SSRI-induced sexual dysfunction in postmenopausal women.
This trial is registered with NCT00568126.
American Psychological Association (APA)
Dording, Christina M.& Schettler, Pamela J.& Dalton, Elizabeth D.& Parkin, Susannah R.& Walker, Rosemary S. W.& Fehling, Kara B.…[et al.]. 2015. A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063835
Modern Language Association (MLA)
Dording, Christina M.…[et al.]. A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063835
American Medical Association (AMA)
Dording, Christina M.& Schettler, Pamela J.& Dalton, Elizabeth D.& Parkin, Susannah R.& Walker, Rosemary S. W.& Fehling, Kara B.…[et al.]. A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063835