Herb-Partitioned Moxibustion Regulates the TLR2NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis
Joint Authors
Wu, Huangan
Liu, Huirong
Liu, Yanan
Dong, Hongsheng
Feng, Xiaoming
Zhou, Zhigang
Zhao, Chen
Wang, Xiaomei
Wu, Luyi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The TLR2/NF-κB signaling pathway plays an important role in the pathomechanism of ulcerative colitis (UC); acupuncture and moxibustion can improve the damage in colonic tissues of UC, but the regulatory mechanism remains unknown.
This study observed the effect of moxibustion on the TLR2/NF-κB signaling pathway at the Tianshu (ST25) and Qihai (CV6) acupuncture points in the UC rat.
The result shows that TLR2, IRAK1, and IKK-b mRNA and protein levels in the colonic mucosa were significantly higher in the UC rats than in the control rats.
Herb-partitioned moxibustion reduced the expression of TLR2, IRAK1, and IKK-b mRNA and proteins in the UC rats.
Similarly, the expression of NF-κB was significantly increased and IFN-β and IL-10 were significantly decreased in the colonic mucosa of UC rats, but herb-partitioned moxibustion reduced the expression of IFN-β and upregulating the expression of IFN-β and IL-10 significantly.
It indicates that herb-partitioned moxibustion can inhibit the expression of multiple signaling molecules of the TLR2 pathway effectively, and it may modulate the excessive local immune response by inhibiting TLR2 signaling, thereby promoting the repair of damaged colonic mucosa.
American Psychological Association (APA)
Wang, Xiaomei& Liu, Yanan& Dong, Hongsheng& Wu, Luyi& Feng, Xiaoming& Zhou, Zhigang…[et al.]. 2015. Herb-Partitioned Moxibustion Regulates the TLR2NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063836
Modern Language Association (MLA)
Wang, Xiaomei…[et al.]. Herb-Partitioned Moxibustion Regulates the TLR2NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063836
American Medical Association (AMA)
Wang, Xiaomei& Liu, Yanan& Dong, Hongsheng& Wu, Luyi& Feng, Xiaoming& Zhou, Zhigang…[et al.]. Herb-Partitioned Moxibustion Regulates the TLR2NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063836