Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Yoo, Sae-Rom
Jeong, Soo-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Oyaksungi-san (OYSGS) is a herbal formula that has been used for treating cardiovascular diseases in traditional Asian medicine.
Here, we investigated the antiadipogenic effect of OYSGS extract in 3T3-L1 adipose cells.
Methods.
3T3-L1 preadipocytes were differentiated into adipocytes with or without OYSGS.
After differentiation, we measured Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH) activity, leptin production, mRNA, and protein levels of adipogenesis-related factors.
Results.
OYSGS extract dramatically inhibited intracellular lipid accumulation in the differentiated adipocytes.
It also significantly suppressed the (GPDH) activity, triglyceride (TG) content, and leptin production by reducing the expression of adipogenesis-related genes including lipoprotein lipase, fatty acid binding protein 4, CCAAT/enhancer-binding protein-alpha (C/EBP-α), and peroxisome proliferator-activated receptor gamma (PPAR-γ).
Furthermore, OYSGS clearly enhanced phosphorylation of AMP-activated protein kinase (AMPK) as well as its substrate acetyl CoA (ACC) carboxylase.
Conclusions.
Our results demonstrate that OYSGS negatively controls TG accumulation in 3T3-L1 adipocytes.
We suggest antiadipogenic activity of OYSGS and its potential benefit in preventing obesity.
American Psychological Association (APA)
Yoo, Sae-Rom& Seo, Chang-Seob& Shin, Hyeun-Kyoo& Jeong, Soo-Jin. 2015. Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063838
Modern Language Association (MLA)
Yoo, Sae-Rom…[et al.]. Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063838
American Medical Association (AMA)
Yoo, Sae-Rom& Seo, Chang-Seob& Shin, Hyeun-Kyoo& Jeong, Soo-Jin. Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063838