Protective and Therapeutic Effects of Chinese Medicine Formula Jiajian Yunvjian on Experimental Cardiac Remodeling after Myocardial Infarction Induced by Coronary Artery Ligation
Joint Authors
Du, Jun
Gu, Wei-liang
Chen, Chang-xun
Wang, Ying
Lv, Jian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
This study was designed to explore the effect and mechanism of a classic Chinese medicine formula Jiajian Yunvjian (JJYNJ) on cardiac remodeling.
Cardiac remodeling after myocardial infarction (MI) model was achieved by coronary artery ligation (CAL).
Methodology.
When dosed orally once daily, the effects of JJYNJ on hemodynamics, left ventricular weight index (LVWI), heart weight index (HWI), concentration, and gene expression of neuroendocrine factors as well as the histomorphological observation were determined.
Results.
After 4 weeks, mild cardiac remodeling in CAL group was characterized compared with sham group, but after 4 weeks of treatment of JJYNJ, hemodynamics improved, HWI reduced, and circulating angiotensin II (Ang II), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), and hydroxyproline (Hyp) concentrations as well as Ang II receptor type 1 (AT1R) mRNA, transforming growth factor β1 (TGF-β1) mRNA, and TNF-α mRNA levels in myocardium were lower than in CAL group.
Decreased plasma aldosterone (ALD) concentration, cross-sectional area of cardiomyocyte, collagen volume fraction (CVF), collagen types I and III, perivascular collagen area (PVCA), and upregulated nitric oxide (NO) levels were observed at the same time.
Conclusions.
These findings suggest that JJYNJ may have a protective and therapeutic function on cardiac remodeling related to MI.
American Psychological Association (APA)
Du, Jun& Gu, Wei-liang& Chen, Chang-xun& Wang, Ying& Lv, Jian. 2015. Protective and Therapeutic Effects of Chinese Medicine Formula Jiajian Yunvjian on Experimental Cardiac Remodeling after Myocardial Infarction Induced by Coronary Artery Ligation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063839
Modern Language Association (MLA)
Du, Jun…[et al.]. Protective and Therapeutic Effects of Chinese Medicine Formula Jiajian Yunvjian on Experimental Cardiac Remodeling after Myocardial Infarction Induced by Coronary Artery Ligation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063839
American Medical Association (AMA)
Du, Jun& Gu, Wei-liang& Chen, Chang-xun& Wang, Ying& Lv, Jian. Protective and Therapeutic Effects of Chinese Medicine Formula Jiajian Yunvjian on Experimental Cardiac Remodeling after Myocardial Infarction Induced by Coronary Artery Ligation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063839