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Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage
Joint Authors
Kim, Hyo Geun
Hwang, Deok-Sang
Oh, Myung Sook
Park, Sodam
Ryu, Jong Hoon
Kim, Hyo Geun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Kyung-Ok-Ko (KOK), a well-known traditional Korean medicinal formula, has long been used to invigorate the essential q i .
This use of KOK may be associated with reproductive ability as a more modern concept.
The protective effect of KOK was evaluated against deterioration of testicular function induced by heat exposure in male mice.
Male fertility was disrupted by scrotal heat stress at 43°C for 5 weeks.
KOK (0.25, 0.50, and 2.00 g/kg/day) was administered orally at 3 h after the stress.
To evaluate the protective effect of KOK, body weight, testicular weight, sperm count, sperm motility, and histopathological changes in the testes were evaluated.
KOK-treated mice significantly recovered their general health, as evidenced by body weight.
KOK-treated mice also showed significantly higher testes weights, sperm counts, and sperm motility than did the heat stress group.
KOK-treated mice significantly recovered the morphological appearance of the seminiferous tubules and seminiferous epithelium.
Furthermore, KOK-treated mice significantly increased antioxidant enzyme activities and reduced the protein expressions of apoptosis in the testes.
KOK significantly protects against heat-induced damage to testicular function in male mice by inhibiting oxidative stress and apoptosis, indicating that KOK may be an effective agent for treatment of heat-induced male infertility.
American Psychological Association (APA)
Hwang, Deok-Sang& Kim, Hyo Geun& Park, Sodam& Kim, Hyo Geun& Ryu, Jong Hoon& Oh, Myung Sook. 2015. Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063841
Modern Language Association (MLA)
Hwang, Deok-Sang…[et al.]. Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063841
American Medical Association (AMA)
Hwang, Deok-Sang& Kim, Hyo Geun& Park, Sodam& Kim, Hyo Geun& Ryu, Jong Hoon& Oh, Myung Sook. Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063841