Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOFMS
Joint Authors
Ya, Li
Li, Jiansheng
Yang, Liping
Tian, Yange
Li, Suyun
Jiang, Suli
Wang, Ying
Song, Xuekun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As a traditional Chinese medicine, Bufei Yishen Formula (BYF) is widely used in China as an effective treatment for chronic obstructive pulmonary disease (COPD).
Because of the component complexity and multiple activities of Chinese herbs, the mechanism whereby BYF affects COPD is not yet fully understood.
Herein, pulmonary function experiments and histomorphological assessments were used to evaluate the curative effect of BYF, which showed that BYF had an effect on COPD.
Additionally, a high performance liquid chromatography quadrupole time-of-flight mass spectrometry (HPLC QTOF/MS) metabonomics method was used to analyze the mechanism of the actions of BYF on rats with COPD induced by a combination of bacteria and smoking.
Partial least squares discriminate analysis (PLS-DA) was used to screen biomarkers related to BYF treatment.
Candidate biomarkers were selected and pathways analysis of these metabolites showed that three types of metabolic pathways (unsaturated fatty acid metabolism-related pathways, phenylalanine metabolism-related pathways, and phospholipid metabolism-related pathways) were associated with BYF treatment.
Importantly, arachidonic acid and related metabolic pathways might be useful targets for novel COPD therapies.
American Psychological Association (APA)
Yang, Liping& Li, Jiansheng& Ya, Li& Tian, Yange& Li, Suyun& Jiang, Suli…[et al.]. 2015. Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOFMS. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063842
Modern Language Association (MLA)
Yang, Liping…[et al.]. Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOFMS. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063842
American Medical Association (AMA)
Yang, Liping& Li, Jiansheng& Ya, Li& Tian, Yange& Li, Suyun& Jiang, Suli…[et al.]. Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOFMS. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063842