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Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations
Joint Authors
Merlugo, Liara
Santos, Marí C.
Sant’Anna, Liane S.
Cordeiro, Everson W. F.
Batista, Luiz A. C.
Miotto, Silvia T. S.
Moreira, Cleci M.
Mendez, Andreas S. L.
Garcia, C. V.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Erythrina species are used in popular medicine as sedative, anxiolytic, anti-inflammatory, and antihypertensive.
In this work, we investigated the chemical composition of extracts obtained from leaves of E.
falcata and E.
crista-galli.
The hypotensive potential of E.
falcata and the mechanism of action were also studied.
The extracts were obtained by maceration and infusion.
The total content of phenolic compounds and flavonoids was estimated by spectrophotometric methods.
The chemical constituents were studied performing a chromatographic analysis by UPLC-ESI-MS.
For in vivo protocols, blood pressure and heart rate were measured by the invasive hemodynamic monitoring method.
Different concentrations of extracts and drugs such as L-NAME, losartan, hexamethonium, and propranolol were administrated i.v.
The results of total phenolic contents for E.
falcata and E.
crista-galli were 1.3193–1.4989 mgGAE/mL for maceration and 0.8771–0.9506 mgGAE/mL for infusion.
In total flavonoids, the content was 7.7829–8.1976 mg RE/g for maceration and 9.3471–10.4765 RE mg/g for infusion.
The chemical composition was based on alkaloids, suggesting the presence of erythristemine, 11β-methoxyglucoerysodine, erysothiopine, 11β-hydroxyerysodine-glucose, and 11-hydroxyerysotinone-rhamnoside.
A potent dose-dependent hypotensive effect was observed for E.
falcata, which may be related to the route of β-adrenergic receptors.
American Psychological Association (APA)
Merlugo, Liara& Santos, Marí C.& Sant’Anna, Liane S.& Cordeiro, Everson W. F.& Batista, Luiz A. C.& Miotto, Silvia T. S.…[et al.]. 2015. Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063845
Modern Language Association (MLA)
Merlugo, Liara…[et al.]. Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063845
American Medical Association (AMA)
Merlugo, Liara& Santos, Marí C.& Sant’Anna, Liane S.& Cordeiro, Everson W. F.& Batista, Luiz A. C.& Miotto, Silvia T. S.…[et al.]. Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063845