The Clinical Value of Oxymatrine in Preventing Lamivudine Induced YMDD Mutation: A Meta-Analysis
Joint Authors
He, Min
Wu, Yu
Wang, Mengmeng
Chen, Wenwen
Jiang, Jian
Yuan, Wei An
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxymatrine (OMTR) is widely used for the treatment of chronic hepatitis B (CHB) in China.
Several reports revealed that combination of OMTR and lamivudine reduced the incidence of tyrosine- (Y-) methionine- (M-) aspartic acid- (D-) aspartic acid (D) (YMDD) mutations in CHB patients.
The aim of this study was to evaluate the clinical value of oxymatrine in preventing lamivudine induced YMDD mutation using meta-analysis of data from published randomized controlled trials (RCTs) and to provide some useful information for clinical treatment and future research of YMDD mutation.
The Cochrane Central Register of Controlled Trials, Medline, Science Citation Index, EMBASE, China National Knowledge Infrastructure, Wanfang Database, and China Biomedical Database were searched to identify RCTs that evaluated the incidence of YMDD-motif mutation to lamivudine therapy and lamivudine plus OMTR therapies in CHB patients.
Data analysis was carried out with the use of RevMan 5.3.2.
The literature search yielded 324 studies, and 16 RCTs matched the selection criteria.
Overall, the incidence of YMDD mutation was significantly lower in patients treated with lamivudine plus OMTR than in patients treated with lamivudine alone (11.14% versus 28.18%; RR: 0.41; 95% CI: 0.33–0.52; p < 0.05 ).
The exact outcome needs to perform rigorously designed, multicenter, and large randomized controlled trials.
American Psychological Association (APA)
He, Min& Wu, Yu& Wang, Mengmeng& Chen, Wenwen& Yuan, Wei An& Jiang, Jian. 2015. The Clinical Value of Oxymatrine in Preventing Lamivudine Induced YMDD Mutation: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063849
Modern Language Association (MLA)
He, Min…[et al.]. The Clinical Value of Oxymatrine in Preventing Lamivudine Induced YMDD Mutation: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063849
American Medical Association (AMA)
He, Min& Wu, Yu& Wang, Mengmeng& Chen, Wenwen& Yuan, Wei An& Jiang, Jian. The Clinical Value of Oxymatrine in Preventing Lamivudine Induced YMDD Mutation: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063849