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Serum Pharmacochemistry Analysis Using UPLC-Q-TOFMS after Oral Administration to Rats of Shenfu Decoction
Joint Authors
Ma, Zengchun
Gao, Yue
He, Jia-le
Zhao, Jia-wei
Wang, Yu-guang
Liang, Qian-de
Tan, Hong-ling
Xiao, Cheng-rong
Tang, Xiang-lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The purpose of this study was to study the serum pharmacochemistry of SFD as well as the material basis through analyzing the constituents absorbed in blood.
The SFD was orally administrated to Wistar rats at 20 g·kg−1, and Ultra Performance Liquid Chromatography (UPLC) fingerprints of SFD were created.
Serum samples were collected for analysis, and further data processing used MarkerLynx XS software.
19 ginsenosides and 16 alkaloids were detected in SFD.
The absorption of alkaloids (mainly monoester diterpenoid alkaloids) increased when Aconitum carmichaeli Debx.
was combined with Panax ginseng, while the ginsenosides remained stable.
Diester diterpenoid alkaloids were not present in the serum samples.
A suitable serum pharmacochemistry method was successfully established to study pharmacological effects and potential improvements in formulation.
This may also be useful for toxicity reduction.
We suspect that the increased absorption of the monoester diterpenoid alkaloids from the mixture of Panax and Radix, compared to the Panax only extract, may be the reason for the combination of the two herbs in popular medicine formulas in China.
American Psychological Association (APA)
He, Jia-le& Zhao, Jia-wei& Ma, Zengchun& Wang, Yu-guang& Liang, Qian-de& Tan, Hong-ling…[et al.]. 2015. Serum Pharmacochemistry Analysis Using UPLC-Q-TOFMS after Oral Administration to Rats of Shenfu Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063856
Modern Language Association (MLA)
He, Jia-le…[et al.]. Serum Pharmacochemistry Analysis Using UPLC-Q-TOFMS after Oral Administration to Rats of Shenfu Decoction. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063856
American Medical Association (AMA)
He, Jia-le& Zhao, Jia-wei& Ma, Zengchun& Wang, Yu-guang& Liang, Qian-de& Tan, Hong-ling…[et al.]. Serum Pharmacochemistry Analysis Using UPLC-Q-TOFMS after Oral Administration to Rats of Shenfu Decoction. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063856