A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer
Joint Authors
Itoh, Yoshiyuki
Mizuno, Mika
Ikeda, Mitsuru
Nakahara, Rie
Kubota, Seiji
Ito, Junji
Okada, Tohru
Kawamura, Mariko
Kikkawa, Fumitaka
Naganawa, Shinji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed to evaluate the radioprotective effect of hydrolyzed rice bran (HRB) on acute gastroenteritis due to chemoradiotherapy for treatment of cervical cancer.
This placebo-controlled, double-blind study was conducted as an exploratory investigation of the colitis-inhibiting effects of HRB in alleviating acute-phase gastrointestinal side effects of chemoradiotherapy.
The study involved 20 patients (10 in the HRB group, 10 in the control group).
The patients in the control group underwent the same chemoradiotherapy regimen as those in the HRB group, but they received a placebo instead of HRB.
The diarrheal side effect assessment score was lower in the HRB than control group, and a trend toward a reduction in diarrhea symptoms was observed with the oral intake of HRB.
Additionally, no significant difference was observed in the administration of intestinal regulators and antidiarrheal agents, but again the assessment score was lower in the HRB than control group, and diarrhea symptoms were alleviated with the oral intake of HRB.
A trend toward no need for strong antidiarrheal agents was seen.
Although this study was an exploratory clinical trial, the results suggest that HRB may relieve diarrhea, an acute-phase gastrointestinal side effect of chemoradiotherapy.
American Psychological Association (APA)
Itoh, Yoshiyuki& Mizuno, Mika& Ikeda, Mitsuru& Nakahara, Rie& Kubota, Seiji& Ito, Junji…[et al.]. 2015. A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063857
Modern Language Association (MLA)
Itoh, Yoshiyuki…[et al.]. A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063857
American Medical Association (AMA)
Itoh, Yoshiyuki& Mizuno, Mika& Ikeda, Mitsuru& Nakahara, Rie& Kubota, Seiji& Ito, Junji…[et al.]. A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063857