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The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide
Joint Authors
Li, Xiaojiang
Li, Baole
Jia, Yingjie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Haoqin Qingdan decoction (HQQD), a modern Chinese formula, has been widely used in Eastern Asia.
Our study focuses on the hepatoprotective effect of HQQD against cyclophosphamide-induced hepatotoxicity.
S180, a kind of ascites tumor cells, was used to establish S180-bearing mice, followed by the injection of cyclophosphamide (CP, 80 mg/kg) every other day for 5 times.
HQQD was used intragastrically at the dose of 80 g/kg, 40 g/kg, and 20 g/kg twice a day for 12 days.
HL-7702 hepatic cell line was incubated with HQQD-medicated serum.
Then we detected the effects of HQQD on (i) tumor suppression; (ii) morphological examination; (iii) SOD, MDA, GSH, ALT, and AST; (iv) cleaved caspase-3 expression and (v) cellular viability.
CP caused dramatic elevations of AST, ALT, and MDA, while HQQD notably attenuated these elevations.
SOD and GSH were notably increased, which were efficiently attenuated by HQQD.
CP injection significantly increased apoptosis by increasing cleaved caspase-3 expression, which was obviously inhibited by HQQD, accompanied by the improvement of cells viability.
Histopathological examinations supported the above findings.
Therefore, HQQD may protect liver tissue through attenuating oxidative stress and the caspase-3-dependent intrinsic apoptosis induced by CP, which suggests the potentially therapeutic effect of HQQD in the use of alkylating agent for cancer chemotherapy.
American Psychological Association (APA)
Li, Xiaojiang& Li, Baole& Jia, Yingjie. 2015. The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063861
Modern Language Association (MLA)
Li, Xiaojiang…[et al.]. The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063861
American Medical Association (AMA)
Li, Xiaojiang& Li, Baole& Jia, Yingjie. The Hepatoprotective Effect of Haoqin Qingdan Decoction against Liver Injury Induced by a Chemotherapeutic Drug Cyclophosphamide. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063861