Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease
Joint Authors
Fan, Jing-Yu
Han, Jing-Yan
Deng, Jing-Na
Li, Juan
Mu, Hong-Na
Wang, Ming-Xia
Ye, Fei
Liu, Yu-Ying
Pan, Chun-Shui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was to explore the protective effects of Deepure tea against insulin resistance and hepatic steatosis and elucidate the potential underlying molecular mechanisms.
C57BL/6 mice were fed with a high fat diet (HFD) for 8 weeks to induce the metabolic syndrome.
In the Deepure tea group, HFD mice were administrated with Deepure tea at 160 mg/kg/day by gavage for 14 days.
The mice in HFD group received water in the same way over the same period.
The age-matched C57BL/6 mice fed with standard chow were used as normal control.
Compared to the mice in HFD group, mice that received Deepure tea showed significantly reduced plasma insulin and improved insulin sensitivity.
Deepure tea increased the expression of insulin receptor substrate 2 (IRS-2), which plays an important role in hepatic insulin signaling pathway.
Deepure tea also led to a decrease in hepatic fatty acid synthesis and lipid accumulation, which were mediated by the downregulation of sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthesis (FAS), and acetyl-CoA carboxylase (ACC) proteins that are involved in liver lipogenesis.
These results suggest that Deepure tea may be effective for protecting against insulin resistance and hepatic steatosis via modulating IRS-2 and downstream signaling SREBP-1c, FAS, and ACC.
American Psychological Association (APA)
Deng, Jing-Na& Li, Juan& Mu, Hong-Na& Liu, Yu-Ying& Wang, Ming-Xia& Pan, Chun-Shui…[et al.]. 2015. Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063863
Modern Language Association (MLA)
Deng, Jing-Na…[et al.]. Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063863
American Medical Association (AMA)
Deng, Jing-Na& Li, Juan& Mu, Hong-Na& Liu, Yu-Ying& Wang, Ming-Xia& Pan, Chun-Shui…[et al.]. Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063863