Identification of a Potential Target of Capsaicin by Computational Target Fishing
Joint Authors
Ye, Xuan-yi
Ling, Qing-zhi
Chen, Shao-jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Capsaicin, the component responsible for the pungency of chili peppers, shows beneficial effects in many diseases, although the underlying mechanisms remain unclear.
In the present study, the potential targets of capsaicin were predicted using PharmMapper and confirmed via chemical-protein interactome (CPI) and molecular docking.
Carbonic anhydrase 2 was identified as the main disease-related target, with the pharmacophore model matching well with the molecular features of capsaicin.
The relation was confirmed by CPI and molecular docking and supported by previous research showing that capsaicin is a potent inhibitor of carbonic anhydrase isoenzymes.
The present study provides a basis for understanding the mechanisms of action of capsaicin or those of other natural compounds.
American Psychological Association (APA)
Ye, Xuan-yi& Ling, Qing-zhi& Chen, Shao-jun. 2015. Identification of a Potential Target of Capsaicin by Computational Target Fishing. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063867
Modern Language Association (MLA)
Ye, Xuan-yi…[et al.]. Identification of a Potential Target of Capsaicin by Computational Target Fishing. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063867
American Medical Association (AMA)
Ye, Xuan-yi& Ling, Qing-zhi& Chen, Shao-jun. Identification of a Potential Target of Capsaicin by Computational Target Fishing. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063867