Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats
Joint Authors
Abu, Mohd Nazri
Samat, Suhana
Kamarapani, Norathirah
Nor Hussein, Fuzina
Hassan, Hamzah Fansuri
Ismail, Wan Iryani Wan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition.
Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated with T.
crispa (HFDTC), and the high fat diet treated with orlistat (HFDO).
After sixteen weeks of treatment, blood and organs were harvested for analyses.
Results showed that T.
crispa significantly (p < 0.05) reduced the body weight (41.14 ± 1.40%), adiposity index serum levels (4.910 ± 0.80%), aspartate aminotransferase (AST: 161 ± 4.71 U/L), alanine aminotransferase (ALT: 100.95 ± 3.10 U/L), total cholesterol (TC: 18.55 ± 0.26 mmol/L), triglycerides (TG: 3.70 ± 0.11 mmol/L), blood glucose (8.50 ± 0.30 mmo/L), resistin (0.74 ± 0.20 ng/mL), and leptin (17.428 ± 1.50 ng/mL) hormones in HFDTC group.
The insulin (1.65 ± 0.07 pg/mL) and C-peptide (136.48 pmol/L) hormones were slightly decreased but within normal range.
The histological results showed unharmed and intact liver tissues in HFDTC group.
As a conclusion, T.
crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet.
American Psychological Association (APA)
Abu, Mohd Nazri& Samat, Suhana& Kamarapani, Norathirah& Nor Hussein, Fuzina& Ismail, Wan Iryani Wan& Hassan, Hamzah Fansuri. 2015. Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063869
Modern Language Association (MLA)
Abu, Mohd Nazri…[et al.]. Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063869
American Medical Association (AMA)
Abu, Mohd Nazri& Samat, Suhana& Kamarapani, Norathirah& Nor Hussein, Fuzina& Ismail, Wan Iryani Wan& Hassan, Hamzah Fansuri. Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063869