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Buckwheat Honey Attenuates Carbon Tetrachloride-Induced Liver and DNA Damage in Mice
Joint Authors
Cheng, Ni
Wu, Liming
Zheng, Jianbin
Cao, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Buckwheat honey, which is widely consumed in China, has a characteristic dark color.
The objective of this study was to investigate the protective effects of buckwheat honey on liver and DNA damage induced by carbon tetrachloride in mice.
The results revealed that buckwheat honey had high total phenolic content, and rutin, hesperetin, and p-coumaric acid were the main phenolic compounds present.
Buckwheat honey possesses super DPPH radical scavenging activity and strong ferric reducing antioxidant power.
Administration of buckwheat honey for 10 weeks significantly inhibited serum lipoprotein oxidation and increased serum oxygen radical absorbance capacity.
Moreover, buckwheat honey significantly inhibited aspartate aminotransferase and alanine aminotransferase activities, which are enhanced by carbon tetrachloride.
Hepatic malondialdehyde decreased and hepatic antioxidant enzymes (superoxide dismutase and glutathione peroxidase) increased in the presence of buckwheat honey.
In a comet assay, lymphocyte DNA damage induced by carbon tetrachloride was significantly inhibited by buckwheat honey.
Therefore, buckwheat honey has a hepatoprotective effect and inhibits DNA damage, activities that are primarily attributable to its high antioxidant capacity.
American Psychological Association (APA)
Cheng, Ni& Wu, Liming& Zheng, Jianbin& Cao, Wei. 2015. Buckwheat Honey Attenuates Carbon Tetrachloride-Induced Liver and DNA Damage in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063870
Modern Language Association (MLA)
Cheng, Ni…[et al.]. Buckwheat Honey Attenuates Carbon Tetrachloride-Induced Liver and DNA Damage in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063870
American Medical Association (AMA)
Cheng, Ni& Wu, Liming& Zheng, Jianbin& Cao, Wei. Buckwheat Honey Attenuates Carbon Tetrachloride-Induced Liver and DNA Damage in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063870