Molecular Pathogenesis of MALT Lymphoma
Joint Authors
Troppan, Katharina
Wenzl, Kerstin
Neumeister, Peter
Deutsch, Alexander
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright.
MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine.
Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma.
However, these genetic abnormalities alone are not sufficient for malignant transformation.
There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process.
This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.
American Psychological Association (APA)
Troppan, Katharina& Wenzl, Kerstin& Neumeister, Peter& Deutsch, Alexander. 2015. Molecular Pathogenesis of MALT Lymphoma. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063910
Modern Language Association (MLA)
Troppan, Katharina…[et al.]. Molecular Pathogenesis of MALT Lymphoma. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063910
American Medical Association (AMA)
Troppan, Katharina& Wenzl, Kerstin& Neumeister, Peter& Deutsch, Alexander. Molecular Pathogenesis of MALT Lymphoma. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063910