Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease
Joint Authors
Ao, Ran
Wang, Ying
Zhnag, Dao-Rong
Du, Ya-Qi
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Objective.
The present meta-analysis investigated the contribution of TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms in increasing the risk of inflammatory bowel disease (IBD).
Methods.
Databases were searched using a combination of keywords related to TLR4 and IBD.
Relevant studies were selected based on strict inclusion and exclusion criteria.
Meta-analysis of the data extracted from the selected studies was performed using CMA 2.0 statistical analysis software.
Results.
Out of the 70 studies retrieved by database search, only 13 studies were eligible for inclusion in this meta-analysis and these 13 studies contained a total number of 4409 IBD patients and 5693 healthy controls.
The meta-analysis results demonstrated that TLR4 rs4986790A>G polymorphism is associated with an increased risk of IBD (allele model: OR = 1.268, 95% CI = 1.124~1.431, and P<0.001; dominant model: OR = 1.240, 95% CI = 1.090~1.409, and P=0.001).
Similarly, TLR4 rs4986791C>T polymorphism also conferred an increased risk of IBD (allele model: OR = 1.259, 95% CI = 1.092~1.453, and P=0.002; dominant model: OR = 1.246, 95% CI = 1.072~1.447, and P=0.004).
Conclusion.
Our meta-analysis results demonstrate that TLR4 rs4986790A>G and rs4986791C>T genetic polymorphisms are associated with the etiopathogenesis of IBD.
American Psychological Association (APA)
Ao, Ran& Wang, Ying& Zhnag, Dao-Rong& Du, Ya-Qi. 2015. Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1063920
Modern Language Association (MLA)
Ao, Ran…[et al.]. Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease. Gastroenterology Research and Practice No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1063920
American Medical Association (AMA)
Ao, Ran& Wang, Ying& Zhnag, Dao-Rong& Du, Ya-Qi. Role of TLR4 rs4986790A>G and rs4986791C>T Polymorphisms in the Risk of Inflammatory Bowel Disease. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1063920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063920