Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer
Joint Authors
Grabowski, Krzysztof
Nienartowicz, Mirosław
Zarębski, Paweł
Fudalej, Kamila
Markocka-Mączka, Krystyna
Diakowska, Dorota
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC).
Material and Methods.
The serum levels of study factors were measured in 73 patients with CRC and in 35 healthy controls who were gender- and BMI-matched to the study group.
Concentrations of oxLDL, o-LAB, and CEA were detected in ELISA tests.
Serum lipids, lipoproteins, and glucose levels were also coestimated.
Results.
Age and o-LAB were significant factors of CRC presence, but results of logistic regression analysis showed that both were weak predictors of CRC risk.
Concentration of o-LAB was significantly higher in colon cancer than in rectal cancer, especially when the cancer was located in the right section of colon.
Serum CEA levels were significantly elevated in the advanced stage of disease, primary tumor progression, angiolymphatic invasion, and presence of distant metastasis.
Conclusions.
Obtained results have demonstrated that oxLDL and o-LAB were not satisfactory risk markers of CRC.
Although significant relation between o-LAB level and CRC is observed, it may be rather the result of individual differences in the host immune responses against cancer.
American Psychological Association (APA)
Diakowska, Dorota& Grabowski, Krzysztof& Nienartowicz, Mirosław& Zarębski, Paweł& Fudalej, Kamila& Markocka-Mączka, Krystyna. 2015. Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063922
Modern Language Association (MLA)
Diakowska, Dorota…[et al.]. Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer. Gastroenterology Research and Practice No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1063922
American Medical Association (AMA)
Diakowska, Dorota& Grabowski, Krzysztof& Nienartowicz, Mirosław& Zarębski, Paweł& Fudalej, Kamila& Markocka-Mączka, Krystyna. Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1063922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063922