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Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia
Joint Authors
Scott, R. J.
Serrano-Fernandez, Pablo
Dymerska, Dagmara
Kurzawski, Grzegorz
Derkacz, Róża
Sobieszczańska, Tatiana
Banaszkiewicz, Zbigniew
Roomere, Hanno
Oitmaa, Eneli
Metspalu, Andres
Janavičius, Ramūnas
Elsakov, Pavel
Razumas, Mindaugas
Petrulis, Kestutis
Irmejs, Arvīds
Miklaševičs, Edvīns
Lubiński, Jan
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers.
We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition.
Material and Methods.
DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls), Latvia (81 cases and controls), Lithuania (123 cases and controls), and Poland (795 cases and controls).
Results.
Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample).
Conclusions.
The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.
American Psychological Association (APA)
Serrano-Fernandez, Pablo& Dymerska, Dagmara& Kurzawski, Grzegorz& Derkacz, Róża& Sobieszczańska, Tatiana& Banaszkiewicz, Zbigniew…[et al.]. 2015. Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063931
Modern Language Association (MLA)
Serrano-Fernandez, Pablo…[et al.]. Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063931
American Medical Association (AMA)
Serrano-Fernandez, Pablo& Dymerska, Dagmara& Kurzawski, Grzegorz& Derkacz, Róża& Sobieszczańska, Tatiana& Banaszkiewicz, Zbigniew…[et al.]. Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063931