Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis
Joint Authors
Chen, Yaqin
Wu, Gang
Zhang, Hongmin
Xu, Hua
Li, Hong
Chen, Ling
Yang, Yixuan
Hu, Peng
Zhang, Dazhi
Ren, Hong
Hu, Huaidong
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Graft reinfection with hepatitis C (HCV) after liver transplantation is a significant problem in transplant hepatology.
This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation.
Methods.
We searched electronic databases up to July 31, 2013, to obtain relevant research reports that satisfied the inclusion criteria.
Meta-analyses were done on randomized controlled trials (RCTs) and nonrandomized trials.
Results.
A meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 326 patients (171 of whom accepted interferon-based antiviral therapy).
The treatment group was found to have higher virological response (VR) rates than controls at 12, 24, 48, and 72 weeks.
Patients in the antiviral group had higher sustained virological response (SVR) rates and lower mean alanine aminotransferase levels relative to controls at 48 weeks, but more total serious adverse events (AEs) than controls.
Conclusions.
Interferon-based treatment has some efficacy in the treatment of HCV graft reinfection following liver transplantation.
American Psychological Association (APA)
Chen, Yaqin& Wu, Gang& Zhang, Hongmin& Xu, Hua& Li, Hong& Chen, Ling…[et al.]. 2015. Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063933
Modern Language Association (MLA)
Chen, Yaqin…[et al.]. Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063933
American Medical Association (AMA)
Chen, Yaqin& Wu, Gang& Zhang, Hongmin& Xu, Hua& Li, Hong& Chen, Ling…[et al.]. Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063933