Vascular Endothelial Injury and Apoptosis in Rats with Severe Acute Pancreatitis
Joint Authors
Ge, Ning
Xia, Qing
Yang, Zhong-Hua
Ding, Qun-Fang
Zeng, Zhi
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We explored mechanisms of vascular endothelial injury that lead to systemic multiple organ failure by detecting the soluble endothelial protein C receptor (sEPCR), von Willebrand factor (vWF), serum nitric oxide (NO), and tumor necrosis factor alpha (TNF-α) and Bcl-2 mRNA and Bax mRNA expression in a severe acute pancreatitis (SAP) rat model.
Compared to controls, the levels of TNF-α, vWF, and sEPCR were significantly increased in the experimental group at 12 hours and 24 hours and the NO level was significantly decreased.
After 12 hours, the aortic endothelial apoptosis index and Bax mRNA expression in aortic endothelial cells had increased in the experimental group, but Bcl-2 mRNA levels had decreased.
All these changes appeared at both 12 h and 24 hours.
The results indicated that vascular endothelial injury and apoptosis markers were elevated in SAP.
Endothelial injury and increased apoptosis in the experimental group were related to the increased expression of TNF-α.
American Psychological Association (APA)
Ge, Ning& Xia, Qing& Yang, Zhong-Hua& Ding, Qun-Fang& Zeng, Zhi. 2015. Vascular Endothelial Injury and Apoptosis in Rats with Severe Acute Pancreatitis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063939
Modern Language Association (MLA)
Ge, Ning…[et al.]. Vascular Endothelial Injury and Apoptosis in Rats with Severe Acute Pancreatitis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063939
American Medical Association (AMA)
Ge, Ning& Xia, Qing& Yang, Zhong-Hua& Ding, Qun-Fang& Zeng, Zhi. Vascular Endothelial Injury and Apoptosis in Rats with Severe Acute Pancreatitis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063939