Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study
Joint Authors
Guo, Xiaozhong
Chen, Jiang
Li, Hongyu
Xia, Chunlian
Peng, Ying
Dai, Junna
Hou, Yue
Deng, Han
Li, Jing
Qi, Xingshun
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of gastroesophageal varices (GEVs) in patients with liver cirrhosis.
Methods.
We enrolled 118 patients with liver cirrhosis who underwent the tests for the four serum liver fibrosis markers and upper gastrointestinal endoscopy at the same admissions.
The predictive values of the four serum liver fibrosis markers were evaluated by the areas under the receiving operator characteristics curves (AUROCs) with 95% confidence intervals (CIs).
Results.
The prevalence of GEVs was 88% (104/118).
The AUROCs for HA, LN, PIIINP, and CIV levels in predicting the presence of GEVs were 0.553 (95% CI: 0.458 to 0.644, P=0.5668), 0.490 (95% CI: 0.397 to 0.584, P=0.9065), 0.622 (95% CI: 0.528 to 0.710, P=0.1099), and 0.560 (95% CI: 0.466 to 0.652, P=0.4909).
The PIIINP level at a cut-off value of 31.25 had a sensitivity of 73.1% and a specificity of 57.1%.
Conclusions.
The present study did not recommend HA, LN, PIIINP, and CIV levels to evaluate the presence of GEVs in liver cirrhosis.
American Psychological Association (APA)
Qi, Xingshun& Li, Hongyu& Chen, Jiang& Xia, Chunlian& Peng, Ying& Dai, Junna…[et al.]. 2015. Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063947
Modern Language Association (MLA)
Qi, Xingshun…[et al.]. Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063947
American Medical Association (AMA)
Qi, Xingshun& Li, Hongyu& Chen, Jiang& Xia, Chunlian& Peng, Ying& Dai, Junna…[et al.]. Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063947