Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma
Joint Authors
Sim, Jongmin
Yi, Kijong
Kim, Hyunsung
Ahn, Hyein
Chung, Yumin
Rehman, Abdul
Jang, Se Min
Lee, Kang Hong
Jang, Kiseok
Paik, Seung Sam
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial.
The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma.
We constructed tissue microarrays and investigated DUSP4 expression by immunohistochemistry.
DUSP4 was more frequently expressed in adenocarcinomas and lymph node/distant metastases compared to that in normal colorectal tissues and tubular adenomas (P<0.001).
Mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (P<0.001).
DUSP4 expression was significantly correlated with older age (P=0.017), male gender (P=0.036), larger tumor size (P=0.014), nonmucinous tumor type (P=0.023), and higher T stage (P=0.040).
Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on both overall survival and disease-free survival in AJCC stage I (P=0.008 and P=0.003, resp., log-rank test) and male gender (P=0.017 and P=0.049, resp., log-rank test).
DUSP4 protein is frequently upregulated in colorectal adenocarcinoma and may play an important role in carcinogenesis and cancer progression and may be a marker of adverse prognosis.
American Psychological Association (APA)
Sim, Jongmin& Yi, Kijong& Kim, Hyunsung& Ahn, Hyein& Chung, Yumin& Rehman, Abdul…[et al.]. 2015. Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063950
Modern Language Association (MLA)
Sim, Jongmin…[et al.]. Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063950
American Medical Association (AMA)
Sim, Jongmin& Yi, Kijong& Kim, Hyunsung& Ahn, Hyein& Chung, Yumin& Rehman, Abdul…[et al.]. Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063950