Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?
Joint Authors
Kladi-Skandali, Athina
Michaelidou, Kleita
Mavridis, Konstantinos
Scorilas, Andreas
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
High throughput methodologies have revealed the existence of an unexpectedly large number of long noncoding RNAs (lncRNAs).
The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers.
The most prominent example of lncRNAs application in routine clinical practice is PCA3, a FDA-approved biomarker for prostate cancer.
Regarding digestive system malignancies, the oncogenic HOTAIR is one of the most widely studied lncRNAs in the preclinical level and has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract.
Here, we provide an overview of recent findings regarding the emerging role of lncRNAs not only as key regulators of cancer initiation and progression in colon, stomach, pancreatic, liver, and esophageal cancers, but also as reliable tumor markers and therapeutic tools.
lncRNAs can be easily, rapidly, and cost-effectively determined in tissues, serum, and gastric juice, making them highly versatile analytes.
Taking also into consideration the largely unmet clinical need for early diagnosis and more accurate prognostic/predictive markers for gastrointestinal cancer patients, we comment upon the perspectives of lncRNAs as efficient molecular tools that could aid in the clinical management.
American Psychological Association (APA)
Kladi-Skandali, Athina& Michaelidou, Kleita& Scorilas, Andreas& Mavridis, Konstantinos. 2015. Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1063958
Modern Language Association (MLA)
Kladi-Skandali, Athina…[et al.]. Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?. Gastroenterology Research and Practice No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1063958
American Medical Association (AMA)
Kladi-Skandali, Athina& Michaelidou, Kleita& Scorilas, Andreas& Mavridis, Konstantinos. Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1063958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063958