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Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice
Joint Authors
Reinke, Daniel
Kritas, Stamatiki
Polychronopoulos, Panagiotis
Skaltsounis, Alexios Leandros
Aligiannis, Nektarios
Tran, Cuong D.
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigated the role of acteoside in the amelioration of mucositis.
C57BL/6 mice were gavaged daily with acteoside 600 μg for 5 d prior to induction of mucositis and throughout the experimental period.
Mucositis was induced by methotrexate (MTX; 12.5 mg/kg; s.c.).
Mice were culled on d 5 and d 11 after MTX.
The duodenum, jejunum, and ileum were collected for myeloperoxidase (MPO) activity, metallothionein (MT) levels, and histology.
Acteoside reduced histological severity scores by 75, 78, and 88% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5.
Acteoside reduced crypt depth by 49, 51, and 33% and increased villus height by 19, 38, and 10% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5.
Acteoside decreased MT by 50% compared to MTX-control mice on d 5.
Acteoside decreased MPO by 60% and 30% in the duodenum and jejunum, respectively, compared to MTX-controls on d 5.
Acteoside alleviated MTX-induced small intestinal mucositis possibly by preventing inflammation.
American Psychological Association (APA)
Reinke, Daniel& Kritas, Stamatiki& Polychronopoulos, Panagiotis& Skaltsounis, Alexios Leandros& Aligiannis, Nektarios& Tran, Cuong D.. 2015. Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063961
Modern Language Association (MLA)
Reinke, Daniel…[et al.]. Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice. Gastroenterology Research and Practice No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063961
American Medical Association (AMA)
Reinke, Daniel& Kritas, Stamatiki& Polychronopoulos, Panagiotis& Skaltsounis, Alexios Leandros& Aligiannis, Nektarios& Tran, Cuong D.. Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063961