Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning
Joint Authors
Aslan, Fatih
Polat, Murat
Albayrak, Bulent
Yilmaz, Omer
Cerrah, Serkan
Arabul, Mahmut
İpek, Serkan
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background Aim.
In case of high-dose acetaminophen intake, the active metabolite can not bind to the glutathione, thereby inducing cellular necrosis through binding to the cytosol proteins.
This trial was performed to histologically and biochemically investigate whether leptin was protective against liver damage induced by paracetamol at toxic doses.
Material and Method.
In our trial, 30 female rats, divided into 5 groups, were used.
IP leptin administration was performed after an hour in the group of rats, in which paracetamol poisoning was induced.
The groups were as follows: Group 1: the control group, Group 2: 20 µg/kg leptin, Group 3: 2 g/kg paracetamol, Group 4: 2 g/kg paracetamol + 10 µg/kg leptin, and Group 5: 2 g/kg paracetamol + 20 µg/kg leptin.
Results.
The most significant increase was observed in the PARA 2 g/kg group, while the best improvement among the treatment groups occurred in the PARA 2 g/kg + LEP 10 µg/kg group (p < 0.05).
While the most significant glutathione (GSH) reduction was observed in the PARA 2 g/kg group, the best improvement was in the PARA 2 g/kg + LEP 10 µg/kg group (p < 0.05).
Conclusion.
Liver damage occurring upon paracetamol poisoning manifests with hepatocyte breakdown occurring as a result of inflammation and oxidative stress.
Leptin can prevent this damage thanks to its antioxidant and anti-inflammatory efficacy.
American Psychological Association (APA)
Polat, Murat& Cerrah, Serkan& Albayrak, Bulent& İpek, Serkan& Arabul, Mahmut& Aslan, Fatih…[et al.]. 2015. Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063965
Modern Language Association (MLA)
Polat, Murat…[et al.]. Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063965
American Medical Association (AMA)
Polat, Murat& Cerrah, Serkan& Albayrak, Bulent& İpek, Serkan& Arabul, Mahmut& Aslan, Fatih…[et al.]. Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063965