D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome
Joint Authors
Kowlgi, N. Gurukripa
Chhabra, Lovely
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
D-lactic acidosis or D-lactate encephalopathy is a rare condition that occurs primarily in individuals who have a history of short bowel syndrome.
The unabsorbed carbohydrates act as a substrate for colonic bacteria to form D-lactic acid among other organic acids.
The acidic pH generated as a result of D-lactate production further propagates production of D-lactic acid, hence giving rise to a vicious cycle.
D-lactic acid accumulation in the blood can cause neurologic symptoms such as delirium, ataxia, and slurred speech.
Diagnosis is made by a combination of clinical and laboratory data including special assays for D-lactate.
Treatment includes correcting the acidosis and decreasing substrate for D-lactate such as carbohydrates in meals.
In addition, antibiotics can be used to clear colonic flora.
Although newer techniques for diagnosis and treatment are being developed, clinical diagnosis still holds paramount importance, as there can be many confounders in the diagnosis as will be discussed subsequently.
American Psychological Association (APA)
Kowlgi, N. Gurukripa& Chhabra, Lovely. 2015. D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063992
Modern Language Association (MLA)
Kowlgi, N. Gurukripa& Chhabra, Lovely. D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063992
American Medical Association (AMA)
Kowlgi, N. Gurukripa& Chhabra, Lovely. D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063992